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Be informed!

We want you to be informed. That is why below, you will find a variety of different sources about each highly potent ingredient contained in GlucoMiracle. Please read through the information as you please and make the decision that is best for you!

Evidence to prove the effectiveness of GlucoMiracle Ingredients

Gymnema sylvestre

  • has a long history of use in the treatment of diabetes in Ayurvedic medicine. 
  • clinical studies have shown that Gymnema sylevestre improves blood glucose control without the aid of oral medication (Baskaran et al., 1990)
  • stimulates insulin release from β-cells and islets (Persaud et al., 1999)
  • demonstrated blood lipid lowering effects (Daisy et al., 2009)

Bitter Melon

  • Numerous studies indicate that bitter melon and a constituent charantin, help in the management of blood sugar among individuals with type 2 diabetes and at risk populations.  (Fuangchan et al., 2011; Tsai et al., 2012; Ahmed et al., 1999; Khanna et al., 1981; Leatherdale et al., 1981; Welihinda et al., 1986; Srivastava et al., 1993; Dans et al., 2007; Basch et al., 2003)
  • M. charantia and specific constituents have shown significant hypoglycemic effects, lowers glycosylated hemglobin (HbA1c) and lowers blood cholesterol. (Inayat-ur-Rahman et al., 2009; Khanna et al., 1981)
  • restores architecture of islets of Langerhans and regenerates beta cells. (Fernandes et al., 2007; Singh and Gupta, 2007; Ahmed et al., 1998)
  • Research also suggests that bitter melon increases pancreatic insulin secretion, increases hepatic glycogen synthesis and decreases hepatic gluconeogenesis among other beneficial mechanistic effects promoting health glucose levels. (Basch et al., 2003)
  • Bitter melon extract may also slow the progression of microalbuminuria and diabetic nephropathy.  (Grover et al., 2001)
  • promotes insulin release (Fernandes et al., 2007), insulin-like activity    (Cummings et al., 2004)

Image for Testimonial

GlucoMiracle is incredibly supportive for high blood sugar levels I know because it REALLY helped my blood sugar levels drop significantly in just a short period of time. GlucoMiracle is AWESOME! I never felt so supportive for a product like this before.
- Reginald T. – Dallas, TX

Curcumin (Turmeric)

  • Turmeric has a long history of use in Ayurvedic medicine for the treatment of inflammatory disorders, with the active ingredient being curcumin.
  • Curcumin mediates its anti-inflammatory effects through the down-regulation of cytokines, inflammatory transcription factors and enzymes that promote inflammation.
  • Curcumin has also been shown to play a role in obesity and weight reduction (Ejaz et al., 2009)
  • Attenuates proteinuria  in type 2 diabetics (Khajehdehi P et al., 2010)
  • lowers blood glucose and cholesterol  (Sawatpanich et al., 2010; El-Moselhy et al., 2011; Seo et al., 2008)

Chromium Polynicotinate

  • Chromium deficiency is associated with metabolic syndrome and type 2 diabetes, thus supplementation is key
  • Chromium polynicotinate is a superior form of chromium for use in type 2 diabetes (Preuss et al., 2008)
  • Improves insulin sensitivity, decreases systolic blood pressure, improves blood lipids; helps maintain body weight; decreases free radical formation and damage in liver and kidney tissues  (Preuss et al., 2008; Lee et al., 1994; Anderson et al., 1997; Rabinovitz et al., 2004; Martin et al., 2006)

Thank you!

We hope that this information has helped you be more informed and ready to take the next step in living a healthier life. Please feel free to check out our 4 Step Action Plan page to learn more about how to manage your blood sugar levels.

References:

Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients. Bangladesh Medical Research Council Bulletin 1999;25(1): 11–3.

Ahmed I, Adeghate E, Sharma AK, Pallot DJ, Singh J. Effects of momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat. Diabetes Research and Clinical Practice 1998;40(3): 145–51.

Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786-91.

Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9.

Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extracts from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990;30:295–300.

Cummings E, Hundal HS, Wackerhage H, Hope M, Belle M, Adeghate E, et al.Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Molecular and Cellular Biochemistry 2004;26(1-2):99–104.

Daisy P, Eliza J, Mohamed Farook KA. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol. 2009;126:339–44.

Dans AM, Villarruz MV, Jimeno CA, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol 2007;60:554-9.

Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57 ⁄ BL mice. J. Nutr. 2009; 139: 919–25.

El-Moselhy MA, Taye A, Sharkawi SS, El-Sisi SF, Ahmed AF. The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-alpha and free fatty acids. Food Chem. Toxicol. 2011; 49: 1129–40.

Fernandes NP, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med. 2007;7:29.

Fernandes NP, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized momordica charantia fruit extract. BMC Complementary and Alternative Medicine 2007;24(7):29.

Fuangchan A, Sonthisombat P, Seubnukarn T, Chanouan R, Chotchaisuwat P, Sirigulsatien V, Ingkaninan K, Plianbangchang P, Haines ST Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients. J Ethnopharmacol. 2011 Mar 24;134(2):422-8.

Grover JK, Vats V, Rathi SS, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol 2001;76:233-8.

Inayat-ur-Rahman, Malik SA, Bashir M, Khan R, Iqbal M. Serum sialic acid changes in non-insulin-dependant diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomedicine. 2009 May;16(5):401-5.

Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol. 2011 Nov;45(5):365-70

Khanna P, Jain SC, Panagariya A, Dixit VP. Hypoglycemic activity of polypeptide-p from a plant source. J Nat Prod. 1981;44:648–55

Leatherdale BA, Panesar RK, Singh G, Atkins TW, Bailey CJ, Bignell AH. Improvement in glucose tolerance due to Momordica charantia (karela). British Medical Journal (Clinical Research Ed.) 1981;282(6279):1823–4.

Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 1994;17:1449-52.

Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32.

Persaud SJ, Al-Majed H, Raman A, Jones PM. Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol. 1999;163:207–12.

Preuss HG, Echard B, Perricone NV, Bagchi D, Yasmin T, Stohs SJ. Comparing metabolic effects of six different commercial trivalent chromium compounds. J Inorg Biochem. 2008 Nov;102(11):1986-90.

Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucosevand lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82.

Sawatpanich T, Petpiboolthai H, Punyarachun B, Anupunpisit V Effect of curcumin on vascular endothelial growth factor expression in diabetic mice kidney induced by streptozotocin. J. Med. Assoc. Thai. 2010; 93(Suppl. 2): S1–8.

Seo KI, Choi MS, Jung UJ et al. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db ⁄ db mice. Mol. Nutr. Food Res. 2008; 52: 995–1004.

Singh N, Gupta M. Regeneration of beta cells in islets of Langerhans of pancreas of alloxan diabetic rats by acetone extract of Momordica charantia (Linn.) (bitter gourd) fruits. Indian Journal of Experimental Biology 2007;45(12): 1055–62. 

Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.

Tsai CH et al. Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial. Nutrition Journal 2012 Jan 13; 11:4.

Welihinda J, Karunanayake EH, Sheriff MH, Jayasinghe K. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. Journal of Ethnopharmacology 1986;17(3):277–82.